A study coordinated by the European Parliament provides a critical analysis of the future role of macro-regions in the implementation of European Territorial Cooperation. On the basis of a literature review and case studies, the study offers an assessment of potential benefits in the development of new macro-regional strategies as well as the most common risks and difficulties in their implementation. Recommendations are derived to inform the position of the European Parliament on how it can efficiently support the creation and implementation of new macro-regional strategies.